Value of plasma ADMA in predicting cardiac structure and function of patients with chronic kidney diseases

YE Jian-hua;ZHOU Xiao-ling;CHEN Meng-hua.

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Chinese Journal of Nephrology ›› 2012, Vol. 28 ›› Issue (9) : 683-686.
临床研究

Value of plasma ADMA in predicting cardiac structure and function of patients with chronic kidney diseases

  • YE Jian-hua, ZHOU Xiao-ling, CHEN Meng-hua.
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Abstract

Objective To explore the predicting value of plasma asymmetric dimethylarginine (ADMA) in cardiac structure and function of patients with chronic kidney diseases (CKD). Methods A total of 100 CKD patients were enrolled in this cross-sectional study. According to staging of the K-DOQI guideline, CKD patients were divided into five groups. Twenty healthy people were enrolled as control. Plasma level of ADMA was determined by reversed-phase high performance liquid chromatography. Cardiac structure and function were detected by color echocardiography. Results Plasma levels (μmol/L) of ADMA in CKD stage 3 to 5 patients (1.3318±0.4684, 1.5712±0.4210, 2.1093±0.7714) were significantly higher than those in CKD stage 1, 2 patients (0.4387±0.2575, 0.4809±0.2846) and healthy control (0.4611±0.1615) (all P<0.01). Meanwhile, ADMA level of CKD stage 5 was significantly higher as compared to CKD stage 3-4. The left ventricular mass index (LVMI) was significantly higher in stage 4-5 patients than that in stage 1-3 and healthy control. Plasma ADMA was positively correlated with LVMI (r=0.476, P=0.028) and negatively correlated with left ventricular ejection fraction (EF) (r=-0.327, P=0.041). Multivariate stepwise Logistic regression analysis revealed plasma ADMA level was an independent predictors for EF (OR=0.984, P<0.01). Conclusions Plasma level of ADMA begins to increase in CKD patients of stage 3 and rises proportionally to the decline of renal function. Plasma ADMA level is useful in predicting the cardiovascular complications of CKD patients.

Key words

Kidney diseases / chronic / Cardiovascular diseases / Asymmetric dimethylarginine

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YE Jian-hua;ZHOU Xiao-ling;CHEN Meng-hua. . Value of plasma ADMA in predicting cardiac structure and function of patients with chronic kidney diseases [J]. Chinese Journal of Nephrology, 2012, 28(9): 683-686.

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