Objective To report a rare case of renal amyloidosis secondary to Castleman’s disease, and to review literatures concerned. Methods and Results A 43-year-old man, who was followed up for three years, presented proteinuria, anemia and poly-site enlarged lymph nodes. Renal amyloidosis of AA type was diagnosed by pathological examination of renal biopsy samples, and Castleman’s disease of multicentric and plasma cells type was diagnosed by immunology and pathological examination of lymph node biopsy samples. Conclusion Castleman’s disease can result in renal amyloidosis, which pathogenic mechanism may be associated with the abnormal immune states caused by Castleman’s disease.