Typing of amyloidosis in renal biopsies of 205 cases

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Chinese Journal of Nephrology ›› 2013, Vol. 29 ›› Issue (2) : 88-92. DOI: 10.3760/cma.j.issn.1001-7097.2013.02.002

Typing of amyloidosis in renal biopsies of 205 cases

  • YAO Ying, WANG Su-xia, ZHANG You-kang, QU Zhen, LIU Gang, ZOU Wan-zhong.
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Abstract

Objective    To identify the prevalence of different amyloid types in renal biopsies.    Methods    The renal biopsies of 205 patients diagnosed as renal amyloidosis from January 1990 to December 2011 were reassessed. Immunohistochemistry was performed with a penal of antibodies directed against λ-light chain, κ-light chain, amyloid A, fibrinogen, transthyretin, apolipoprotein A1, and lysozyme. Immune electron microscopy and gene analysis were performed when the results of immunohistochemistry were indeterminate.    Results    Among 205 patients, 190 cases (92.7%) were classified as immunoglobulin light chain amyloidosis (AL), 1 (0.5%) case as amyloid A amyloidosis and 1 (0.5%) case as fibrinogen A α-chain amyloidosis. The amyloid types of remaining 13 (6.3%) cases were undetermined. In the AL patients, the distribution of λ and κ was 6.6:1.    Conclusion    AL is the most common form of renal amyloidosis in China, with a predominant light chain type of λ.

Key words

Amyloidosis / Biopsy / Immunohistochemistry / Mutation

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. Typing of amyloidosis in renal biopsies of 205 cases[J]. Chinese Journal of Nephrology, 2013, 29(2): 88-92. DOI: 10.3760/cma.j.issn.1001-7097.2013.02.002.

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